Kinetics for Viral responses

E lps signal 2 is il 5 from t cells and mast cells igm

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Unformatted text preview: cell that is responsible for the interaction with lipids bound to an unusual MHC molecule called CD- 1d. This is how APC present lipids to activate effector T cells. B- 1 B derives signal 1 from extensive crosslinking needs an antigen with repeating epitopes (I.e. LPS) Signal 2 is IL- 5, from T cells and Mast cells. IgM doesn’t need T cell help, only if class switch upon migration to the mucosal surface. BCR has both variable and constant comains Trifunctional: antigen binding, cell surface receptor binding, lectin binding 5 types of antibodies Membrane bound and secreted Recognizes native epitopes (conformational epitopes) Bind antigen directly, no mediator like MHC IgG is the most common antibody type in blood, BCR is heterodimeric. 2 heavy, 2 light chains, divided into about 110 AA in length. High degree of variability in the AA sequence of the first domain (variable)...
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This document was uploaded on 03/23/2014 for the course BIOL 358 at Georgetown.

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