Dendritic cells pass through high endothelial venules

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Unformatted text preview: y. In parallel, the dendritic cell is also taking up the same pathogen. Dendritic cells engulf everything in the surroundings: self and pathogen alike. Dendritic cell takes up the same gram negative bacteria, via phagocytosis. Once it has ligated the pathogen, the dendritic cell changes it’s nature. Stops becoming a phagocyte but instead antigen- presenting cell. The lymph node generates pheromones that attract the presenting dendritic cell. Dendritic cells pass through High Endothelial Venules (HEV). Dendritic cell takes up residence in the paracortical region of lymph node, where T cells are, close to junction of T and B. Sits their, displaying pieces of pathogen. Hands off parts of this antigen to other dendritic cells. It displays pathogen peptide, waiting for T cells to enter the lymph node. As the T cells percolate through, any T cell that has a receptor on its surface that is specific for that piece of the pathogen that is displayed by the dendritic cell, the T cell will be captured by the dendritic cell. Cognate interaction between dendritic and T, signals that are receptor- ligand interactions, cytokines, with a net effect of driving the T lymphocyte into cell division Clonal expansion. The T cell is no longer naïve, but an effector T cell. The next job of the dendritic cluster is to find a B cell with a receptor for the antigen. Motile dendritic cell moves to the B cell- dependent area, find a B cell for antibody production. Macrophages express receptors that enable them...
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This document was uploaded on 03/23/2014 for the course BIOL 358 at Georgetown.

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