Notice that the antigen binding domain paratope binds

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Unformatted text preview: for antigen. Both of these molecules are glycoproteins. They are all part of the immunoglobulin supergene family. Immunoglobulin = antibody, synonymous. The antibody is a four- chain structure. 2 identical heavy chains (green), 2 identical light chains (yellow) Symmetrical and identical. Chains named via molecular mass, historical. The heavy chain linked to other heavy by disulfide bonds, to light chain also. Domain lie structure. Each domain is 110 AA in length. Light chain has 2 domains, heavy has 4 domains. The region between 1st blue and 2nd blue is the hinge region, flexible, allows the arms of the Y to move in space. The AA sequence in the N terminus are highly variable from one antibody molecule to the next. This is the variable domain. This variable domain is on both the light and the heavy chain. The rest of the chains are much more similar from molecule to molecule constant domains. The hypervariable region is the region of the domain that binds the antigen peptide. The interaction between antibody and pathogen in this region. The standard antibody is bivalen, 2 binding sites that are identical. Paratope specificity of binding site. Fab: fragment with antigen binding (red and blue area) B cell receptor in 2 forms. Exists as a membrane- associated glycoprotein (B cell receptor) but also as a free molecule in blood and tissues. Plasma cells secrete antibodies. T cell is ONLY membrane associated. Like an Fab fragment. T cell is essentially a single arm of B. Beta...
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This document was uploaded on 03/23/2014 for the course BIOL 358 at Georgetown.

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