Epithelial Damage

Nitric oxide produced in the phagolysosome has a

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Unformatted text preview: hobic lipids. These are all part of the immunoglobulin supergene family, domain. Endocytic pattern recognition receptors. These are potent oxidizing agents, are very damaging to the pathogen. Nitric oxide produced in the phagolysosome, has a dramatic effect on the vasculature in terms of vasodilatation. Critical to the activation of these enzymes in the acidification of the phagosome. Deleterious effect on the organisms, and brings the pH down to a level where the acidic proteases can be activated. Neutrophil’s only job is phagocytosis. It has these 1˚ and 2˚ granules. Largely partitioned into the ones that contain the acid and the defensins, and those that have the components to generate the toxic O2 radicals. Not a complete partition between the 2. Out on the mucosal surface, we’ve already encountered...
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This document was uploaded on 03/23/2014 for the course BIOL 358 at Georgetown.

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