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Cellular Locations of TLRs

Cellular Locations of TLRs - Cellular Locations of TLRs TLR...

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Cellular’Locations ’of’TLRs ’ TLR-’toll -like’receptor ’ They’recognize’the’conserved’structural’motifs’PAMPs’and’MAMPs Located’on’PM ’ Incorporated’into’the’phagosome ’ These’are’not’simply’cell’surface’receptors’that’are’internalized. Actively’brought’to’the’developing’phagosome. Also’in’the’cytosol. ’ Cell’can’determine’if’extracellular,’in’the’cytosol,’etc. The’fact’that’there’are’only’a’limited’number’of’these’TLR. Low’specificity. ’ They’may’form’heterodimers. ’ The’operate’either’as’homo’or’heterodimers. The’ligation’of’these’ pattern’recognition’receptors’determines’everything’that’ happens’downstream. ’ Adaptive’or’not ’ Memory’or’not ’ Antibodies,’cytotoxic’T’cells,’helper’T All’determined’by’these’receptors. They’recognize’the’different’transcription’pathways’for’producing’cyto’and chemokines’produced. ’ Type’of’chemokines’determines’the’response’of’the’cell. 1 st ’determination:’worth’an’immune’response? If’self,’shouldn±t’do’since’normally’foreign’motifs,’but’might’recognize’ unmethylated’cDNAs.’Mistakes’can’be’made. Class’of’infecti on’ ’type’of’response ’ LPS’ Structures’in’gram’neg’and’positive’ What’sort’of’immune’response> Antibody’ Helper’T’for’macrophage? ’ Level’of’infection:’strength’of’signal’shows’number’of’activated’receptors. Magnitude’of’response ’ Persistence’of’infection:’len gth’of’stimulation’of’response. Duration’of’response ’ Need’for’immediate’vs.’future’defense Effector’vs.’memory’generation ’
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Caspases’act’on’pro -proteins’like’the’complement’cascade. When’the’yellow’is’sensed,’brings’about’the’caspase
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