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Muscle Physiology 1

Units of actinmyosin in parallel and in series from

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Unformatted text preview: keletal/cardiac muscle = striated Orderly arrangement of thick and thin filaments Actin and myosin sarcomere structure next Lots of neuromuscular junctions, interact at the neural end plate The junction creates an invagination of the cell. Units of actin/myosin in parallel, and in series from end to end. Structure at the Molecular Level A band: dark bnd, thick filaments H zone: thick filaments, no overlap M line: link thick filaments I band: thin filament, no overlap Z line: link thin filaments Sarcomere: functional unit of skeletal muscle, from Z line to Z line There are usually 6 thin filaments around the thick filaments. Generation of contractile force Actin: (globular, G/Fibrous F) Contractile protein, can bind to myosin Helical F actin strands basis for thin filament G action is the typical monomer F actin is the polymer Regulatory Proteins Tropomyosin: Fibrous molecules extends over several actins Inhibits myosin binding in muscle at rest Troponin complex: 3 proteins One binds to actin One binds to tropomyosin strand One will reversibly bind Ca2+ (triggers muscle contraction)...
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