Mediated by membrane receptors target response ion

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Unformatted text preview: hanisms of signal Transduction Intracellular mediated responses Most lipophilic ligands Receptors are in cytosol or nucleus Cell response is via gene activation The lipid hormone binds to the hormone response element for immediate response that then changes the levels of transcription and translation. Mediated by membrane receptors Target response: ion movement, enzyme phosphorylation Channel linked Fast ligand- gated channels (electrical activity) Receptor and channel Binding of ligand causes channel to open or close Change in transport of ions through channel causes target response. This is a calcium channel that is messenger dependent Calcium can work with muscles contraction, important for vesicles in secretion Calmodulin binds the free calcium Enzyme- li...
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