Messengers

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Unformatted text preview: through channel causes response The alpha subunit of the g- protein activates the secondary channel protein. Cholera and G- Proteins The cholera toxin binds to the ganglioside The toxin subunit enters G protein activation is sustained Adenylate cyclase is activated cAMP increases extensively protein kinase cascade is the response This causes mass phosphorylation that then forces secretion of chloride ions Further loss of sodium ions from cells Water osmosis into the lumen Reverse of cystic fibrosis G Protein- linked receptors: Secondary Messenger systems When a primary messenger system, messenger has a 1:1 response. Secondary augments and amplifies response. Second Messengers: Binding of first messenger to receptor leads to production of 2nd messenger 2nd...
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This document was uploaded on 03/23/2014 for the course BIOL 175 at Georgetown.

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