222-08 Exam #2

H serrata is a clubmoss fern that is distributed

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: distributed worldwide and grows in the forest, shrubbery, and roadside at an altitude of 300-2700 m. It grows for 8-15 years but has a very low HA content. One ton of dried plant yields 70-90 g of HA. CH3 CH3 H2N N O NH2 MeO H MeO N O Huperzine A (HA) Donepezil Tacrine N Ph Two Current Alzheimers Treatments Clubmoss Clearly a laboratory synthesis would be desirable. Today we will learn about the first synthesis of racemic HA in 1989. Starting from a β-ketoester, it is possible to make racemic HA in only 19 steps. CH3 O H3C O CH3 ( ± ) - HA 19 steps OEt H2N N H O Name ____________________________________________ The Total Synthesis of Huperzine A (HA) Xia, Yan; Kozikowski, Alan, A Practical Synthesis of the Chinese “Nootropic” Agent Huperzine A: A Possible Lead in the Treatment of Alzheimer ’s Disease, J. Am. Chem. Soc. 1989, 111, 4116-4117. QUESTION #8 Q...
View Full Document

This test prep was uploaded on 03/21/2014 for the course CHEM 222 taught by Professor Mcdonald during the Spring '08 term at Emory.

Ask a homework question - tutors are online