Sulfa drugs discovered by gerhard domagk in the 1930s

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Unformatted text preview: al side effects (low toxicity). •  Can be either bacteriosta4c or bactericidal. Usually have a specific target. •  A good an4microbial drug has: –  –  –  –  –  NO severe side effects, must be far more toxic for bacteria than mammalian cells. Low risk/benefit ra4o. Broad spectrum of ac4vity to facilitate rapid medical interven4on. Appropriate bioavailability and pharmacokine4cs (must reach the site of infec4on). Low cost to develop and manufacture. Mode of ac4on Brock Biology of Microorganisms, 13th Edition. Spectrum of ac4vity Brock Biology of Microorganisms, 13th Edition. Synthe4c An4microbial Drugs •  Paul Ehrlich studied selective toxicity in the early 1900s –  Selective toxicity is the ability to inhibit or kill a pathogen without affecting the host –  Salvarsan – one of the first antimicrobial drugs, used to trea...
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