G streptomyces aminoglycosides kanamycin neomycin

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: % of known antibiotics are clinically useful –  Can be modified to enhance efficacy (semisynthetic antibiotics) •  The susceptibility of microbes to different antibiotics varies greatly –  Gram-positive and Gram-negative bacteria vary in their sensitivity to antibiotics. The cell wall is a major factor. •  β-Lactams are one of the most important groups of antibiotics of all time. Include penicillins, cephalosporins, and cephamycins. Bactericidal, bacteriolytic. β- Lactam An4bio4cs: Penicillins •  Penicillins –  Discovered by Alexander Fleming, isolated from Penicillium chrysogenum (mold). –  Primarily effective against gGram-positive bacteria –  Some synthetic forms are effective against some Gram-negative bacteria –  Inhibit cell wall synthesis A. Fleming, Ulster Med J 13, 95–122.2 (1944). Brock Biology of Microorganisms, 13th Edition. β- Lactam An4bio4cs: Cephalosporins •  Cephalosporins –  Produced by the fungus Cephalosporium –...
View Full Document

Ask a homework question - tutors are online