6-Control_of_Microorganisms_Feb7

G streptomyces aminoglycosides kanamycin neomycin

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Unformatted text preview: % of known antibiotics are clinically useful –  Can be modified to enhance efficacy (semisynthetic antibiotics) •  The susceptibility of microbes to different antibiotics varies greatly –  Gram-positive and Gram-negative bacteria vary in their sensitivity to antibiotics. The cell wall is a major factor. •  β-Lactams are one of the most important groups of antibiotics of all time. Include penicillins, cephalosporins, and cephamycins. Bactericidal, bacteriolytic. β- Lactam An4bio4cs: Penicillins •  Penicillins –  Discovered by Alexander Fleming, isolated from Penicillium chrysogenum (mold). –  Primarily effective against gGram-positive bacteria –  Some synthetic forms are effective against some Gram-negative bacteria –  Inhibit cell wall synthesis A. Fleming, Ulster Med J 13, 95–122.2 (1944). Brock Biology of Microorganisms, 13th Edition. β- Lactam An4bio4cs: Cephalosporins •  Cephalosporins –  Produced by the fungus Cephalosporium –...
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