MidtermW08 bibc 120, Crawford

MidtermW08 bibc 120, Crawford - BIBCl 20-Crawford Name...

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Unformatted text preview: BIBCl 20-Crawford Name _____ if ____________________ __ Midterm-W08 1) (30 pts total) Below is a plot showing percent of women with sufficient levels of Vitamin C versus amount of Vitamin C ingested. a) (10 pts) Indicate on the graph where you would find the EAR and the RDA levels. b) (15 pts) Draw a curve on the plot below showing the percent of men with sufficient levels of Vitamin C that you would expect and indicate EAR and RDA levels for men. )(S @09‘ m 9.. /\ til-0% +8 % s3 mom wfl’k SotHs‘cfovA' An, 39;». b»er ox 0’" 50mm 90533?le 09 «kinds. dumb 07,- c) (5 pts) How is RDA different from A1 (what distinguishes them)? R0 (3‘ \\as \3\o\o§‘1£°~\ mam K043 Ptl do“ n 0+ +5 (Sun Mi) 4.9V WM HI +3 KOO: is mom. thuf‘cc Comes dmgl‘mid—EOAS 031 +3 . ~ cm +3 m a Sew?“ M“) M ‘5 “ésgiim BIBCl 20-Crawford Name _____________________________ __ Midterm-W08 2) (40 pts) a) (5 pts) What is the name of the cells that secrete HCl into the stomach? FariMA/l CMS b) (5 pts) What is the name of the cells that store and release pepsinogen (protease precursor) into the stomach? c) (5 pts) Which hormone stimulates the release of HCl and pepsinogen in the stomach? + 5 gag/rm ('2 foreaw addH/MVIM wronfi wasqu d) (5 pts) What region or organ of the GI track secretes the hormone from part C? + Li 2 3w:er PglwicSthCHY ‘ + l -. (74,01).; +6; P Ion‘oregmn‘ va+ 91: +5.me vjuncfion ol- s": r 5+omach ‘ ~ . '~ pylori c Sphincnk 4491 or shaman/1) ' “3'0” ‘(grf‘t’g‘ H W e) (10 pts) What two substance are released by the gall ladder tfaifi‘d digestion of lipids? l E: [*6 6+6) , lecH’hin (f5) ! “I each .eth in addIIHOh 4'0 W 5‘“ fleei‘mm ~I magor SP-euimrg error f) (5 pts) What is released by the pancreas to aid the digestion of lipids? ‘4/ 5: flippng Si 4/ l3 Jug/hammerer 0‘, “pascwhgowuuu (,2 ma “Wat wrong (www.0ch or “Pqu pmo. miramei . . g) (5 pts) What signal produced by the small intestine stlmulates the release the compounds in part B & F? +23 +0001/chlgme in olvooLMwm/S‘t (orimPlied) -2: m—CH’HOYL W 6PM 4’!’ Mod/chc in SHMM and 31: +0: w {0170! in {Waugh ' scone «Pin WM? ‘ llhormone u BIBC 1 20—Crawford Name _____________________________ __ Midterm-W08 3) (45 pts total). a) (10 pts) What is the “Glycemic Index”? Give a definition. , [3+5 43 Change in We levels in response to ingestion of M carboh te equivalent of a specific food relative to pm (or to? glucose). ’5 H; m Aficmim oiwfljmly aoahm + 9. ’\.§ “.4? not 51,9319 glow/K _ l ‘I? Mali/h Pro—loin“: b) (10 pts) What is the “Glycemic Load”? Give a definition. #3 , . Change in Mimosa levels in response to ingestion of a portion Size + S of a specific food relative to a standard (or to glucose). +1 I l U ‘- "lDO‘xn‘i'S wwz Divan ii; {cl-P401 in (91 um@ QVUQ’IS‘I‘GII bloaJQI W or a M .—\,5 L? Hoch )locpfl c) (10 pts) What would you expect the glycemic index of saccharine (an artificial sweetener) to be? Explain. + 5 Because saccharine does not provide any carbohydrate (Qij is non- nutritive), it would not affect blood glucose levels (after 2-3 hr) so Would have a glycemic index of 0. . + S i; .VE SDUA» \Wow“ “F H ‘0“ or a d) (10 pts) What two health risks are associated with foods with high glycemic indices? —Diabetes (or large increases in blood glucose levels) —Cardio vascular disease (or CVD) ‘Am <1 S Y“ “)WS cf MGM (steppe I Absinc’t 'YLc-i‘ gnbaly omnadd b by or Dude/cw) e) (5 pts) You are given two slices of bread with identical ingredients except one has more coarsely ground flour which is digested more slowly. Which would you expect to have the higher glycemic index, the finer or coarser bread? The finer bread. + w ,. 5 Va COkrS-(H (7wg.u( l’W ‘0 (V ijlyCIm/q “F6.” leC 7U€Sllfh) fan/Hr were 4w1camoff Sela);le gr flmSensicle a/ ~mow/zplelc @XPIMMHW ' BIBC 1 ZO-Crawford Name _____________________________ __ Midterm-W08 4) (50 pts) a) (20 pts) Draw the structure of arachidonic acid C20:4 00—6 (you can write out C and H or use a stick diagram). 0 WW“ Hm 7.0 eowons A?“ - Ltdoomto vows, Lip“ '- éofieekxoam‘flj o Q disemme ~ ) ‘ o Ltp’ts “ FNSWUVDKQ Wovxdod (6“ waon, up»; - (Drmc\ covwmudhcaddgm ? b) (5 pts) What essential fatty acid is arachidonic acid derived from? 6pm- Linou‘m 154‘ d c) (15 pts) Aspirin inhibits COX enzymes. What short—term effect would the intake of Aspirin have on the production of: pqukc‘cedif 7 \ K) RM” arachidonic acid: Spas“ Mme “’7— ‘:0" W ado?“ HMS “0 Group 2 Eicosanoids: S‘pis- 2250‘? Group 3 Eicosanoids: Qvis Pentium c) (10 pts) What 2 primary functions do group 2 eicosanoids perform in the body? _ ,- wbwodcbh‘m 5P4) Promo 610% -' pmmok {n‘Flotvnma’Kon BIBC 1 20-Crawford Name _____________________________ __ Midterm-W08 5) (45 pts total) a) (20 pts) In PKU, the amino acid phenylalanine accumulates leading to the production of phenylpyruvate via a transamination reaction with a- ketoglutarate. Given the structure of phenylalanine below, draw the structures of the other reactant and the two products for this reaction. - (QC-9 / i I C 2 \ ( l , A“: C Hz CH | A + \ ‘ L + C “L f' 2. QKL a) ((10 I Q) 69 [an U (.020 \ \cg: 9 '0 C0 C”) b) (20 pts) The amino acid aspartate can be deaminated to form oxaloacetate. Show the structures for the one reactant and two products for this reaction. Co {=9 (50-99 ' 0+7, C l @ l , “,6; N “g9 f O Ll r‘ ransamlnql-mn l, - r 6) “>9 “’1 ® @ c) (5 pts) Is aspartate a glucogenic or ketogenic amino acid? Glucogenic BIBC 1 ZO-Crawford Name _____________________________ __ Midterm-W08 6) (50 pts) a) (10 pts) Below is the structure of cellulobiose, a disaccharide of glucose found in cellulose. What is it about this structure that prevents it from being broken down by our digestive system? Name it and circle relevant region in structure below. allot} “i6 ‘ . bond 0 ' 0H pummel/z 0v 3‘ QWCWWC N0, OH’ or 05. °H cm» Ce Huloloiose b) (5 pts) What enzyme do we lack that prevents us from digesting this disaccharide? ’i 5 $7 — amdmm c) (10 pts) Which part of the GI tract is most benefited by fiber intake? What is the name of the condition that can result from insufficient fiber intake resulting in inflamed bulges in this part of the GI track? *6 CNOH or \OJ/qx \nlregfine *5 @Xvohcuiifis Us: fadivorhwlosmor (may d) (20 pts) What does fiber do to the epithelial lining of the GI track at the cellular level and what is the response (describe 3 events for response)? +6 (lme Plasma member V5 veesoeg «age m] Plasma MCMbYah-L \ We * 5 omsmamcmlmane \S (epaA d ho»qu e) (5 pts) What vitamin or mineral element is required to be present for the response you described in part D? a 5 wow BIBC120-Crawford Name _____________________________ __ Midterm-W08 7) (40 pts total) a) (5 pts) In which organ does most ethanol metabolism occur? liver b)(5 pts) In which organ does the next most metabolism of ethanol occur? Stomach c) (25 pts) Write out the 4 structures and 3 biochemical steps that convert ethanol to Ac-CoA in our bodies (don’t need to write out CoA). Indicate the names of the intermediates, the enzymes that catalyze each step, and any cofactors or cosubstrates (e.g. FAD/FADHz, NAD/NADH). Abe @ Aw” d) (5 pts) Why is the consumption of ethanol along with sedatives dangerous? Ethanol will slow the metabolism of sedatives, which can result in an overdose of sedative. BIBC120-Crawford Name _____________________________ __ Midterm-W08 8) (50 pts) a) (10 pts) Lipids in the blood (blood lipids) are transported as part of what (give general name)? Why are they transported in this way? 44 0 9 Lipoproteins 'l' l 1Q» H W ) VLD L )LDL , 0r Chf/wzic/OI Lipids are hydrophobic and require lipoproteins to be transported in the aqueous environment of the blood. W +5 lipib hr rafho’no i- Need act/“£0145 —-Z M hiya’rhio or allows Hum +0 crass MCMIP/cmes b) (5 pts) What transports blood ipids from the liver to the brain? 4- 5 VlDL .2 Yo/ asziw/ml wroflfi MSWS (Bach) (HDL , YLDL , ch/IoMicron) c) (5 pts) What scavenges and transports cholesterol from the heart to the liver? 4 5 HDL ~Z fo/ it's/Id] (*2/03 answers ~41 Po/fal Veafl (flaw) d) (5 pts) What transports lipids from the small intestine to the liver? +5 Chylomicrons _. Z fax “10’; 1170/24, (yams amaze/5 -5 g, dose i0 warez, hilt Very Whmsgfg‘f/gu e) (10 pts) Pharmaceutical companies search for new drugs that decrease the risk of cardiovascular disease. What two effects on blood lipids would they like to achieve to reduce CVD? + 5 + 5 Lower LDL and raise HDL f) (5 pts) Which form of fat in the human body is the most mobile and has the greatest health risk? +1 for (leaf )Cni arownz +5 Visceral Fat 0f a/lS g) (10 pts) Adipocytes store lipids in the body yet they can directly affect glucose metabolism and the immune system (explains why obese individuals have such high risk of disease). How do adipocytes do this? They release hormones (or signaling compounds) that regulate glucose metabolism and the immune system. + (I; fix release szflflals +3 F0! release, 5134415 4” l eXowfle (l msulm Sei’lSEllH/ih) or mFlax/Imiiofl +3 tor only an aged (;nJ7/«MMa/aafl,elc.> will/I flo “NIMSC; BIBC 1 20-Crawford Name _____________________________ __ Midterm-W08 9) (50 pts total) During fatty acid oxidation in the mitochondria, an oxidation reaction occurs and a dehydrogenation reaction occurs. Show the structures of the reactants and products for each reaction (can abbreviate structures to just show region that reacts). a) (20 pts) Oxidation (of a hydroxyl): 0“ C? Q) “q +20K" 1C_(H PEI-c, u . 7’ A > —C”CFL__\C’_C°~A +20 ..__ VOV jus+ 4K OKFCQmLfor fl {OW EWCo/l QC" /KA $59,143 Vt“ c L‘w‘ 34' PVaéLa/k C4: b) (20 pts) Dehydrogenation: Q? @ A.&CD F’Cfl>~—CHZ~C ‘CxAQR‘CHZC-HAC—(“A 'i’BflD - be Mfic§wjmxo~ka w Vw‘xl <9 A [c7 “(0 wi<$ CW$ Veacgcru‘P 3V" ‘P {/0 xv c "I: " [0 ~€or reu¢¢$rk$ Wu. feet cefcy. c) (5 pts) If your body were deficient in Vitamin Bz (flavin), which if any ' 7 reaction would be affected. Del/“1&1 O§QMQMQ v\ #5 "Keac Fry“ d) (5 pts) If your body were deficient in niacin, which if any reaction 7 would be affected. OX F D Aim)“ 61(- [Qua («‘o n ...
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MidtermW08 bibc 120, Crawford - BIBCl 20-Crawford Name...

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