Stimulants

Methamphetamine is double methylated phenylethylamine

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Unformatted text preview: others •  Cocaethylene –  Similar effects to cocaine –  Greater cardiac toxicity than cocaine –  3 ­5x the half ­life of cocaine –  associated with seizures, liver damage, compromised immune system Cocaine Pharmacodynamics •  Indirect Agonist for –  DA (high affinity) –  NE (high affinity) –  5 ­HT (modest affinity) •  Mechanism: –  Blocks monoamine reuptake –  Blocks Na+ channels –  Acts on NMDA receptor (produces convulsions) Amphetamine Pharmacodynamics •  Indirect Agonist for –  DA (high affinity) –  NE (high affinity) –  5 ­HT (low affinity) •  Mechanisms: –  Blocks monoamine reuptake –  Inhibit vesicular storage –  Inhibit MAO metabolism –  Reverses reuptake (promotes NT release) Amphetamine methylated phenylethylamine. Methamphetamine is double methylated phenylethylamine. Tolerance, Withdrawal, Addic%on •  High abuse potenAal (Schedule...
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This note was uploaded on 03/21/2014 for the course COGS 174 taught by Professor Pineda during the Winter '11 term at UCSD.

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