Stimulants

New treatment approaches immunological anabodies made

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Unformatted text preview: 2) •  Physical and psychological dependence •  Tolerance to euphoria, appeAte suppression; sensiAzaAon to psychomotor •  Withdrawal –  Physically mild to moderate (hunger, faAgue, anxiety, irritability, depression, panic a@acks, dysphoric syndrome) •  Dysphoric syndrome (1 5 days aqer the crash): characterized by decreased acAvity, amoAvaAon, intense boredom and anhedonia, intense craving for cocaine. May last 1 ­10 weeks. –  Anhedonia from biogenic amine depleAon? –  Intense cravings •  Route of administraAon important to addicAon risk Pharmacotherapies Treatment of withdrawal: •  Alpha ­blockers •  Chlorpromazine: DA antagonist (also blocks alpha receptors) •  Haloperidol (anApsychoAc – 50x more potent than chlorpromazine). •  Alprazolam (Xanax  ­ benzodiazepine) for panic a@acks. •  AnAdepressants (fluoxeAne or desipramine). •  Diazepam (Valium) for seizures  ­ binds to benzodiazepene site of GABAa receptor. New Treatment Approaches IMMUNOLOGICAL •  AnAbodies made against cocaine, to break ­down the molecule and stop its effects. •  Undergoing Phase III trials in US •  An inacAve cholera toxin protein – a@ach inacAvated cocaine •  Immune system makes anAbodies against both •  When individual takes cocaine, anAbodies bind to it and...
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