Neurobiological eects 1 mdma increases oxytocin levels

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Unformatted text preview: e (~ 2hrs) –  rush of energy –  feeling of euphoria, –  happiness, •  Plateau (~ 2 ­3 hrs) –  Less intense pleasure –  OverheaCng –  BoosCng/stacking: taking more of drug •  Come down (~1 ­2 hrs) •  AJer effects (~3 ­24 hrs) What comes aHer the high ? •  Hungover feeling and depression— e ­tarded •  Moodiness, anxiety, and paranoia •  Irritability •  Loss of appeCte •  Insomnia •  Chills or sweaCng •  General Credness Long ­term effects •  Long ­lasCng changes –  Possible brain damage •  Tolerance –  Need greater amounts for the same effects •  Dependence –  Unable to socialize without MDMA PharmacokineXcs •  Dose: ~ 80 ­160mg (500mg – fatal) •  Route: Usually oral (high bioavailability from GI tract) •  Onset: 30 ­60 minutes •  Peak: ~1 ­2 hours •  Half ­life: ~ 8 hours •  DuraCon: 3 ­12 hours Pharmacodynamics •  Indirect agonist for –  5...
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This note was uploaded on 03/21/2014 for the course COGS 174 taught by Professor Pineda during the Winter '11 term at UCSD.

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