Opiate receptors and eect of agonist mu1 1 analgesia

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Unformatted text preview: pression Dependence Peripheral Neuropathy Spinal disease Visual impairment Mood instability Respiratory Respiratory depression Respiratory disease (pneumonia, TB) Gastrointestinal Decreased propulsions Decreased digestive secretions Constipation Eyes Pupillary contraction Kidneys Inhibition of urinary voiding reflex Kidney disease Sexual Reduced libido Irregular menstruation Pharmacodynamics •  Opiates bind to opioid receptors, including the –  mu, delta, epsilon, kappa receptors •  These G ­protein ­ coupled receptors are involved in the transmission of pain signals. Opiate Receptors and effect of Agonist Mu1 (µ1) analgesia, euphoria Mu2 (µ2) constipation, respiratory depression Kappa spinal analgesia, dysphoria Delta unknown NeurotransmiHers Endorphins, Dynorphins, Enkephalins,… •  Called natural opiates •  Involved in glucose regula5on •  natural neural pep5des that bind to opioid receptors to produce euphoric effects •  Released by brain when exposed to opiates NeurotransmiHers GABA •  Affects dopami...
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This note was uploaded on 03/21/2014 for the course COGS 174 taught by Professor Pineda during the Winter '11 term at UCSD.

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