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1992 dsi a reducon in inhibitory gaba release dse

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Unformatted text preview: dynamics •  Mimics ac*on of endogenous anandamide and sn2 arachidonylglycerol (2 ­AG) •  Direct agonist for cannabinoid (CB) receptors, found in both CNS (CB1) and periphery (CB2) •  CB1 receptors are –  Metabotropic –  Primarily presynap*c heteroreceptors –  Mostly inhibitory Devane et al., 1988 •  Inhibits ACh, Glu •  Complex dose ­related effects on reuptake and release of DA and NE •  Loca*on ­specific effects on DA CB Receptor Localiza1on •  •  •  •  •  •  •  •  •  Cortex Thalamus Hippocampus Cerebellum Striatum Accumbens Amygdala VTA Re*na CB(1) receptor is densely distributed in areas of the brain related to motor control, cogni1on, emo1onal responses, mo1vated behavior and homeostasis Depolariza1on ­induced suppression of inhibi1on (DSI) – short term plas1city DSI was discovered in 1992 by Vincent et al., (1992) DSI: a reduc*on in inhibitory GABA release DSE: a reduc*on in excitatory glutamate release; endocannabinoid role not as clear Acute Effects •  Analgesia •  Euphoria •  Disinhibi*on •  Disrupted alen*on •  Seda*on •  Increased appe*te •  Impaired short ­term memory and learning •  An*emesis •  Impaired mul...
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