G 11hydroxydelta9thc tesng done on thccooh an inacve

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Unformatted text preview: dioxide leaves blood Healthy Lung Diseased Lung Marijuana Use Marijuana Use Perceived Risk and Marijuana Use THC Pharmacokine1cs •  Absorp*on –  Inhaled (smoked) –  Oral (tea, food) •  Distribu*on –  Peak blood levels in about 10 minutes –  Significant depot binding due to high lipid solubility •  Bioavailability –  10 ­25% THC Pharmacokine1cs (cont) •  Metabolism and Elimina*on –  Metabolized almost en*rely by liver –  Half ­life 20 ­30+ hours (1 ­10 days) –  More than 24 metabolites, some of which are psychoac*ve (e.g. 11 ­hydroxy ­delta ­9 ­THC) –  Tes*ng done on THC ­COOH (an inac*ve metabolite), can be detected for several weeks –  Excreted via feces (2/3) and urine (1/3) Endocannabinoids –  First receptor discovered in 1988 •  1992 first endocannabinoid discovered •  arachidonyl ethanolamide ­ named anandamide  ­  CB1 receptors expressed in the brain, especially in the hippocampus, cortex, cerebellum, and the basal ganglia.  ­  CB2 receptors are absent from the brain but are expressed mainly in the immune *ssues.  ­  New evidence suggests a CB3 receptor. THC Pharmaco...
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