Lecture 8+9 - Neurotransmitters

metabotropic with either moderately fast indirect

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Unformatted text preview: ptor types (metabotropic) •  α1, β1 ­2 (postsynapDc, excitatory) •  α2 (autoreceptor, inhibitory) Major NE Pathway •  Locus Coeruleus  throughout brain [vigilance and aZenDveness] Serotonin •  Varying excitatory and inhibitory behavioral effects •  Biosynthesis: Tryptophan 5 ­HTP Tryptophan Hydroxylase 5 ­HT 5 ­HT Decarboxylase •  At least 14 receptor types, all metabotropic and postsynapDc except: •  5 ­HT1A,B,D (autoreceptors) – found in CNS •  5 ­HT3 (inhibitory, ionotropic) – found in the intesDnes Major 5 ­HT Pathways •  Dorsal Raphe Nuclei  cortex, striatum •  Medial Raphe Nuclei  cortex, hippocampus Roles in: Mood EaDng Sleep and dreaming Arousal Pain Aggression Indirect Monoamine Agonists •  MAOIs Iproniazid •  Reuptake blockers –  Tricyclic anDdepressants •  Imipramine •  Desipramine  ­ SSRIs –  Cocaine & Amphetamine ~ NeuropepDdes •  •  •  •  Low concentraDon in brain (picomolar) Large vesicles Co ­localized with other transmiZers Circu...
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This note was uploaded on 03/21/2014 for the course COGS 174 taught by Professor Pineda during the Winter '11 term at UCSD.

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