Lecture 8+9 - Neurotransmitters

As a means to prioridze likes for andcipatory

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Unformatted text preview: its –  Interneuronal •  •  •  •  •  Modulatory funcDons Mostly inhibitory Virtually all metabotropic Slow acDng, long duraDon (10 ­1000 ms) Examples: Enkephalins, Endorphins, Oxytocin, Vasopressin, Opioids Opioids •  β ­endorphin –  made from proopiomelanocorDn (POMC) –  produced in pituitary gland, hypothalamus, brain stem •  Enkephalin –  made from proenkephalin (PENK) –  produced throughout brain and spinal cord •  Dynorphin –  made from prodynorphin (PDYN) –  produced throughout brain and spinal cord Opioids Receptors Receptor mu delta kappa High affinity ligands β ­endorphin, enkephalins enkephalins dynorphins •  Opioids act at all opioid receptors, but with different affiniDes •  Distributed throughout brain and spinal cord, especially in limbic areas •  Some overlap but quite disDnct localizaDons Opioid Receptors (cont.) •  Metabotropic, with either –  moderately fast indirect acDon on ion channels –  long ­term acDon via changes in gene expression • Most analgesic effects from mu receptor acDon •  Some analgesic effects from delta •  Man...
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