Lecture 8+9 - Neurotransmitters

Because they are structurally very similar various

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Unformatted text preview: Endorphins (END) Gamma ­aminobutyric acid (GABA) Glutamate (GLU) Drugs Associated with NeurotransmiEers Why do people have drugs of choice ? • Dopamine  ­ amphetamines, cocaine, ETOH • Serotonin  ­ LSD, ETOH • Endorphins  ­ opioids, ETOH • GABA  ­ benzodiazepines, ETOH • Glutamate –ETOH • Acetylcholine  ­ nicoDne, ETOH •  Anandamide – Marijuana Amino Acid NTs •  High concentraDon in brain (micromolar) •  Circuits –  CorDco ­corDcal –  Sensory ­motor •  Point ­to ­point communicaDon •  Consistently excitatory or inhibitory –  Mainly ionotropic receptors but do have metabotropic receptors •  Fast acDng, short duraDon (1 ­5 ms) •  Examples: Glutamate, Aspartate, GABA, Glycine GABA and Glutamate . •  Because they are structurally very similar, various drugs affect the presence of GLU and GABA in the synapDc gap and increase or decrease acDon potenDals. Glutamate •  Principal excitatory NT •  Biosynthesized as byproduct of cell metabolism •  Removed by reuptake •  Elevated levels  neurotoxic •  4 receptor types –  NMDA –  AMPA Ionotropic –  Kainate –  mGluR  ­ Metabotropic NMDA Binding Sites •  4 outside cell The specific subunit composiDon of each receptor...
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This note was uploaded on 03/21/2014 for the course COGS 174 taught by Professor Pineda during the Winter '11 term at UCSD.

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