Lecture 8+9 - Neurotransmitters

Dopamine rewardingmodvadng eects biosynthesis tyrosine

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Unformatted text preview: nomolar) •  Circuits –  Single ­source divergent projecDons –  Mainly midbrain to cortex •  Modulatory funcDons –  Excitatory or inhibitory as a funcDon of receptor •  More metabotropic receptors than ionotropic, but plenty of both •  Slow acDng, long duraDon (10 ­1000 ms) •  Examples: Acetylcholine, Epinephrine, Norepinephrine, Dopamine, Serotonin Acetylcholine •  Mostly excitatory effects Removal Synthesis Acetyl CoA + Choline Choline Acetyltransferase (ChAT) CoA + ACh •  2 receptor types •  NicoDnic (ionotropic) •  Muscarinic (metabotropic) Ach Acetylcholine Esterase (AChE) Acetate + Choline Major ACh Pathways •  Dorsolateral Pons  mid/hindbrain [REM sleep] •  Basal Forebrain  cortex [Learning (esp. perceptual), AZenDon] •  Medial Septum  Hippocampus [Memory] Monoamines •  Catecholamines Dopamine  ­ DA •  Indolamines Serotonin  ­ 5 ­HT –  Dopaminergic –  Serotonergic Norepinephrine  ­ NE –  Noradrenergic Epinephrine  ­ E –  Adrenergic ~ Monoamines (DA, NE, 5 ­HT) •  Modulatory (can have both excitatory and inhibitory effects ­ varies by receptor) •  Recycled by reuptake transporter •  Excess NT in terminal broken down by –  monoamine oxidase (MAOA/B) –...
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This note was uploaded on 03/21/2014 for the course COGS 174 taught by Professor Pineda during the Winter '11 term at UCSD.

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