Lecture 8+9 - Neurotransmitters

Eg pardal agonists or antagonists theory of drug acon

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: through cell membrane seven Dmes (transmembrane domains) They do not possess a channel or pore 3.  4.  Theory of Drug Ac<on Emil Fischer s Lock and Key Hypothesis (1890)    Every lock has its own key    If the key is not precise, the lock does not open    The drug is the key that has to fit the target specifically and producDvely Theory of Drug Ac<on Corollary of Lock & Key Hypothesis OH O HO    O O Does not explain why some keys open doors parDally? …… e.g., parDal agonists or antagonists Theory of Drug Ac<on Daniel Koshland s Induced ­Fit Hypothesis (1958)    At least two steps …… step 1 is iniDal binding and step 2 is a change in structure of the receptor (and/or drug)    Receptor is flexible! …… can wrap around the drug Common NeurotransmiEers Involved in Dependence Probable funcDonal dysregulaDon: •  •  •  •  •  •  Dopamine (DA) Serotonin (SER) Acetylcholine (ACh)...
View Full Document

Ask a homework question - tutors are online