Lecture 6+7 - Pharmacology Basics

Agonistsantagonists full par3al directcompe33ve

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Unformatted text preview: can be several types of interac3ons between medica3ons: cumula3ve, addi3ve, synergis3c, and antagonis3c. Cumula3ve Effects Hi Drug B Response Drug A Lo Time The condi3on in which repeated administra3on of a drug may produce effects that are more pronounced than those produced by the first dose. Addi3ve Effects Hi A+B Response A B Lo Time The effect of two chemicals is equal to the sum of the effect of the two chemicals taken separately, eg., aspirin and motrin. Synergis3c Effects A+B Hi Response A B Lo Time The effect of two chemicals taken together is greater than the sum of their separate effect at the same doses, e.g., alcohol and other drugs Antagonis3c Effects Hi A+B Response A B Lo Time The effect of two chemicals taken together is less than the sum of their separate effect at the same doses Pharmacodynamics •  Receptor –  target/site of drug ac3on (e.g. gene3cally ­coded proteins embedded in neural membrane) •  Lock and key or induced...
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This note was uploaded on 03/21/2014 for the course COGS 174 taught by Professor Pineda during the Winter '11 term at UCSD.

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