Lecture 6+7 - Pharmacology Basics

Cumula3ve eects hi drug b response drug a lo time the

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Unformatted text preview: •  Some3mes occurs in an acute dose (e.g. amphetamine) •  Can develop across drugs (cross ­ sensi3za3on) It is possible to develop tolerance to some side effects AND sensi3za3on to other side effects of the same drug Mechanisms of Tolerance and Sensi&za&on •  Pharmacokine0c –  changes in drug availability at site of ac3on (decreased bioavailability) –  Decreased absorp3on –  Increased binding to depot sites •  Pharmacodynamic –  changes in drug ­receptor interac3on –  G ­protein uncoupling –  Down regula3on of receptors Other Mechanisms of Tolerance and Sensi&za&on •  Psychological As the user becomes familiar with the drug’s effects, s/he learns tricks to hide or counteract the effects. Set (expecta3ons) and seung (environment) Mo3va3onal Habitua3on Classical and instrumental condi3oning (automa3c physiological change in response to cues) •  Metabolic The user is able to break down and/or excrete the drug more quickly due to repeated exposure. Increased excre3on Drug ­drug Interac3ons •  Pharmacokine3c and pharmacodynamic –  With pharmacokine3c drug interac3ons, one drug affects the absorp3on, distribu3on, metabolism, or excre3on of another. –  With pharmacodynamic drug interac3ons, two drugs have interac3ve effects in the brain. –  Either type of drug interac3on can result in adverse effects in some individuals. –  In terms of efficacy, there...
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