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Lecture 6+7 - Pharmacology Basics

G alcohol can develop across drugs cross tolerance

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Unformatted text preview: jects 50 0 ED50 0 DRUG DOSE X Therapeu&c Index •  Effec3ve dose (ED50) = dose at which 50% popula3on shows response •  Lethal dose (LD50) =dose at which 50% popula3on dies •  TI = LD50/ED50, an indica3on of safety of a drug (higher is beqer) ED50 LD50 Potency •  Rela3ve strength of response for a given dose –  Effec3ve concentra3on (EC50) is the concentra3on of an agonist needed to elicit half of the maximum biological response of the agonist –  The potency of an agonist is inversely related to its EC50 value •  D ­R curve shirs ler with greater potency Efficacy •  Maximum possible effect rela3ve to other agents •  Indicated by peak of D ­R curve •  Full agonist = 100% efficacy •  Par3al agonist = 50% efficacy •  Antagonist = 0% efficacy •  Inverse agonist =  ­100% efficacy Comparisons C HI B A Average Response Magnitude LO 0 DRUG DOSE X Tolerance (desensi&za&on) •  Decreased response to same dose with repeated (constant) exposure •  or more drug needed to achieve same effect •  Right ­ward shir of D ­R curve •  Some3mes occurs in an acute dose (e.g. alcohol) •  Can develop across drugs (cross ­ tolerance) •  Caused by compensatory mechanisms that oppose the effects of the drug Sensi&za&on •  Increased response to same dose with repeated (binge ­like) exposure •  or less drug needed to achieve same effect •  Ler ­ward shir in D ­R curve...
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