Lecture 5 - Brain Basics

5 10 25 10 200 150 100 0 0 1 2 3 4 time after

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Unformatted text preview: 300 NICOTINE 250 0 400 % of Basal Release Accumbens 1100 1000 900 800 700 600 500 400 300 200 100 0 % of Basal Release % of Basal Release Effects of Drugs on Dopamine Release 0 1 2 3 4 Time After Cocaine Accumbens 5 hr MORPHINE Dose (mg/kg) 0.5 1.0 2.5 10 200 150 100 0 0 1 2 3 4 Time After Morphine 5hr Di Chiara and Imperato, PNAS, 1988 Drugs make your brain really happy….. BUT only when your brain is on drugs and higher and higher doses. Normal Brain Brain on Drugs Repeated use of drugs trigger compensatory processes and may end up satura>ng the brain s reward systems    individual can become condi>oned/habituated/adapted to the intense level of drug ­induced pleasure (develops tolerance or sensi4za4on)    the normal level of natural rewards are no longer experienced as very pleasurable, and   aeer chronic use, the brain s reward systems becomes so  changed that nothing is pleasurable – not even the drugs! Drugs can change your brain so that natural events are...
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This note was uploaded on 03/21/2014 for the course COGS 174 taught by Professor Pineda during the Winter '11 term at UCSD.

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