Lecture 5 - Brain Basics

Homeostac changes to postsynapc receptor density as a

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Unformatted text preview: ;ons remain stable and rela>vely constant. Homeostasis requires a sensor to detect changes, an effector mechanism that can vary that condi>on and a nega>ve feedback connec>on between the two. Homeosta>c Changes to Postsynap>c Receptor Density as a Func>on of the Amount of NeurotransmiYer Released Upregulation Downregulation Dopamine/Opioids: Brain s incen>ve reward systems Ac>va>on of reward center produces a wan>ng and liking response Natural events ac>vate these reward systems Natural Events Elevate Dopamine Levels SEX 200 % of Basal DA Output NAc shell 150 100 50 Empty Box Feeding 200 150 100 15 10 5 0 0 0 60 120 Time (min) Di Chiara et al., Neuroscience, 1999. 180 Copulation Frequency DA Concentration (% Baseline) FOOD Female Present Sample Number 1 2 3 4 5 6 7 8 Fiorino and Phillips, J. Neuroscience, 1997. Mounts Intromissions Ejaculations Drugs ac>vate your reward systems since they act on the same receptors AMPHETAMINE DA DOPAC HVA 0 1 2 3 4 Time After Amphetamine Accumbens Caudate 150 100 0 1 2 3 hr Time After Nicotine COCAINE DA DOPAC HVA 200 100 0 5 hr 250 % of Basal Release 200 Accumbens...
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This note was uploaded on 03/21/2014 for the course COGS 174 taught by Professor Pineda during the Winter '11 term at UCSD.

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