Lecture 5 - Brain Basics

Your brain chemistry your drug history your drug

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Unformatted text preview: no longer pleasurable Chronic drug taking ….reorganizes the liking and wan>ng systems Brain on drugs after tolerance Brain on drugs for an extended period … drugs may no longer be pleasurable but you s>ll want them… The brain now has a disease… it s a different brain under constant stress Addicted When the switch gets flips depends on …. your brain chemistry…. your drug history…. your drug history…. Normal and other factors Even 80 days following detox, a methamphetamine user s dopamine transporter system (right) hasn t recovered to normal levels (lee) Cocaine has long las>ng effects Normal Cocaine Abuser (10 da) Cocaine Abuser (100 da) At high enough doses, Ecstasy destroys nerve fibers DA Receptors and the Response to Methylphenidate (MP) Low DA receptor high low Dopamine receptor level High DA receptor As a group, subjects with low receptor levels found MP pleasant while those with high levels found MP unpleasant Adapted from Volkow et al., Am. J. Psychiatry, 1999. Drugs not only affect the brain, but also affect the body Gross Brain Anatomy Forebrain Midbrain Hindbrain (Brainstem = Midbrain + Hindbrain - Cerebellum) Hindbrain •  Medulla •  Pons •  Cerebellum Medulla •  caudal end of brainstem; rostral end of spinal cord •  connects rest of brain to sp...
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