Hallucinogens

Ka acid or bloer odorless colorless tasteless

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Unformatted text preview: 0’s –  Clinical and therapeuDc studies in 50’s/60’s Categories of hallucinogens •  AnDcholinergic •  Indolamine ­like –  LSD –  Psilocybin –  DMT –  Ibogaine •  Catecholamine ­like –  Mescaline –  MDMA –  Atropine –  Scopolamine • DissociaDve anaestheDcs –  Ketamine –  PCP •  Other –  Muscimol –  Salvinorin A Category 1: Indoleamine ­like •  Structurally similar to serotonin •  Examples: –  LSD (lysergic acid diethylamide) –  Psilocybin (“magic mushrooms”) –  DMT (dimethyltryptamine) •  Agonists at 5 ­HT2A receptor LSD LSD •  Lysergic Acid Diethylamide –  A.k.a. Acid or blo[er –  Odorless, colorless, tasteless •  Administered orally –  Liquid droplets, blo[er paper, or sugar cubes •  Easily crosses BBB •  Onset is 20 ­60 minutes •  DuraDon is 4 ­12 hours –  Half ­life is 3 ­5 hours •  Mostly eliminated within 2 ­3 days LSD •  Synthesized by Albert Hoffman in 1938 –  Derived from lysergic acid of ergot fungus –  Ergot fungus itself has some hallucinogenic properDes •  Salem witch trials? •  Effects discovered by accident in 1943 –  Hoffman absorbs some through skin and has first LSD trip LSD and culture •  CIA and MKULTRA (late 50...
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This note was uploaded on 03/21/2014 for the course COGS 174 taught by Professor Pineda during the Winter '11 term at UCSD.

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