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129 129 rate and regioselectivity in rate

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Unformatted text preview: trophilic Aromatic Substitution Electrophilic Rate and Regioselectivity in EAS Rate When considering reaction of benzene rings that already have a substitutent there are two questions: 1) How does the substituent affect the rate of reaction? 2) How does the substituent affect the regioselectivity? Substituents and Rate of EAS Consider the rate of nitration of these three compounds: Toluene reacts 20 times faster than benzene. Trifluoromethyl benzene reacts 40,000 times slower than benzene. Substituents and Rate of EAS The rate of reaction is related to the electron density on the benzene ring. The π-electron density is shown as red in the electr...
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