Alternative sources for carbocations any reaction

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Unformatted text preview: ions Any reaction that generates a carbocation can be used to produce the electrophile, e.g. protonation of an alkene: This provides an industrial synthesis of styrene: 12.7 Friedel Crafts Acylation of Benzene Friedel Molecules with two Chirality Centers Acylation uses acyl halides: acyl chloride The acyl cation is the active electrophile: Most of the positive charge is on the carbon. Mechanism of Acylation Step 1. Addition of the electrophile. Step 2. Deprotonation. Preparation of Acyl Chlorides Acyl chlorides are prepared from carboxylic acids using thionyl chloride. Alternative Sources of Acyl Cation Carboxy...
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