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Palladium-Catalyzed Cross-Coupling Palladium Catalyzed Cross-Coupling
Nobel Prize (2010) to Heck, Negishi and Suzuki.
Organotin reagents (Stille Coupling): Organozinc (Negishi): Palladium Catalyzed Cross-Coupling
Organoboron (Suzuki): Alkene (Heck): General Mechanism
Oxidative addition – transmetalation – reductive elimination Mechanism and the Heck Reaction.
π-Complex intermediate. C-O and C-N Bond Formation
Homogeneous Catalytic Hydrogenation Homogeneous Catalytic Hydrogenation
Wilkinson’s catalyst soluble in many organic solvents: Example: Selective for less substituted alkenes.
Selective for alkenes over carbonyls. Homogeneous Catalytic Hydrogenation
Syn addition: Active catalyst: Homogeneous Catalytic Hydrogenation
Stereoselective addition: Mechanism of the Hydrogenation
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- Fall '08