11 1411 palladium catalyzed cross coupling palladium

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Unformatted text preview: nce: 14.11 14.11 Palladium-Catalyzed Cross-Coupling Palladium Catalyzed Cross-Coupling Nobel Prize (2010) to Heck, Negishi and Suzuki. Organotin reagents (Stille Coupling): Organozinc (Negishi): Palladium Catalyzed Cross-Coupling Organoboron (Suzuki): Alkene (Heck): General Mechanism Oxidative addition – transmetalation – reductive elimination Mechanism and the Heck Reaction. π-Complex intermediate. C-O and C-N Bond Formation C-O 14.12 14.12 Homogeneous Catalytic Hydrogenation Homogeneous Catalytic Hydrogenation Wilkinson’s catalyst soluble in many organic solvents: Example: Selective for less substituted alkenes. Selective for alkenes over carbonyls. Homogeneous Catalytic Hydrogenation Syn addition: Active catalyst: Homogeneous Catalytic Hydrogenation Stereoselective addition: Mechanism of the Hydrogenation Ste...
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