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► Coronary artery emboli, secondary to cholesterol, air, or the products of sepsis
► Cocaine, amphetamines, and ephedrine
► Coronary anomalies, including aneurysms of the coronary arteries
► Increased afterload or inotropic effects, which increase the demand on the myocardium Causes continued
► Risk factors for atherosclerotic plaque formation include the following: Age
Hypercholesterolemia and hypertriglyceridemia, including inherited lipoprotein disorders
Poorly controlled hypertension
Type A personality
Sedentary lifestyle Diagnosis of AMI ( Acute Myocardial Infarction ) Cardiac disease is the #1 cause of death in the United States #1 Symptoms, physical examination , and patient history but there are many causes of chest pain other than AMI #2 EKG … only 50% reliable may be normal even during AMI #3 Laboratory tests (Troponin I , CKMB , Myoglobin , BNP) Cardiac cellular necrosis following ischemic event causes soluble proteins to “leak” into the plasma When coronary arteries are blocked (ischemic event ) cardiac tissue is deprived of oxygen and dies, and dead cardiac tissue cells “spill their guts” into the plasma Lab Studies: Lab Studies: Myoglobin
► Soluble heme protein
Present in all muscle cells, cardiac and skeletal
Plasma myoglobin is elevated in various forms of muscle damage surgery, strenuous exercise, degenerative muscle diseases and physical trauma
Myoglobin can also be elevated from decreased renal clearance
Relatively low molecular weight , water solubility and high cellular cytoplasm concentrations cause myoglobin to...
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This document was uploaded on 03/22/2014.
- Spring '14