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Clinical Chemistry 2 collection of specimens

Thenucleus oftenhastwolobesconnectedby

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Unformatted text preview: ount is considerably less, it may be due to a viral infection such as influenza, hepatitis, or rubella. EOSINOPHIL EOSINOPHIL This granulocyte has large granules (A) which are acidophilic and appear pink (or red) in a stained preparation. The nucleus often has two lobes connected by a band of nuclear material. The granules contain digestive enzymes that are particularly effective against parasitic worms in their larval form. These cells also phagocytize antigen ­ antibody complexes. These cells account for less than 5% of the WBC's. Increases beyond this amount may be due to parasitic diseases, bronchial asthma or hay fever. Eosinopenia may occur when the body is severely stressed. BASOPHIL BASOPHIL The basophilic granules in this cell are large, stain deep blue to purple, and are often so numerous they mask the nucleus. These granules contain histamines (cause vasodilation) and heparin (anticoagulant). In a Differential WBC Count we rarely see these as they represent less than 1% of all leukocytes. If the count showed an abnormally high number of these cells, hemolytic anemia or chicken pox may be the cause. LYMPHOCYTE LYMPHOCYTE The lymphocyte is an agranular cell with very clear cytoplasm which stains pale blue. Its nucleus is very large for the size of the cell and stains dark purple. This cell is much smaller than the three granulocytes (which are all about the same size). These cells play an important role in our immune response. The T­lymphocytes act against virus infected cells and tumor cells. The B­lymphocytes produce antibodies. This is the second most numerous leukocyte, accounting for 25­35% of the cells counted in a Differential WBC Count. When the number of these cells exceeds the normal amount, one would suspect infectious mononucleosis or a chronic infection. Patient...
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