Selection Coefficient Simulation

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Unformatted text preview: 0.4 0.3 0.2 0.1 0.0 0 10 20 30 40 50 60 Generat ions 70 80 90 100 How it works This sheet explains how the main worksheet works. It is protected to prevent accidental changes. Review of Hardy-Weinberg Equation Consider a gene with two alleles R and r. R is dominant, r is recessive. Frequency for R is p, for r is q. Using the Hardy-Weinberg equation, the relative proportion of the RR, Rr, and rr genotypes are p2, 2pq, and q2 respectively. p2 + 2pq + q2 = 1 Adapting the Hardy-Weinberg Equation to model selection Fitness coefficient is s Because R is completely dominant, the fitness for RR and Rr are the same and is 1+ s. The fitness for rr is 1. In this model, selection operates on the ratios calculated by the Hardy-Weinberg Equation. Instead of the relative proportion being p2 + 2pq + q2 = 1, after selection, the relative proportions are p2(1 + s) + 2pq(1 + s) + q2 The next generation of p can be calculated by counting up the total number of R alleles and dividing by the total number of all alleles (twice the number of individuals because of diploidy.) Next generation p =...
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## This lab report was uploaded on 03/26/2014 for the course BIOL 1407 taught by Professor Staff during the Spring '08 term at Blinn College.

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