Alterations in Blood Flow-patho

Cholesterol rich begins in childhood and in the

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Unformatted text preview: ts the large and medium-sized arteries of Effects almost every human in societies in which cholesterol-rich foodstuffs are abundant. cholesterol-rich Begins in childhood and, in the absence of Begins accelerating factors, develops slowly until it is widespread in old age. May be accelerated by a wide variety of genetic and environmental factors. It has been calculated that atherosclerosis is the underlying cause of about 50% of all deaths. Risk Factors for Atherosclerosis Risk Modifiable Smoking Hypertension Glucose intolerance Hyperlipidemia Obesity Weight fluctuations/ sedentary life-style Ineffective stress management Nonmodifiable Family history Age Gender Ethnicity Atherosclerosis 1. 2. 2. 3. Low-density serum lipoproteins breach intimal layer Low-density Simultaneously, platelets aggregate at the site Media smooth muscle cells, normally confined to the other Media tunicas, drawn to the intima where they proliferate tunicas, 4. Result: atherosclerotic plaque, primarily composed of Result: plaque primarily smooth muscle cells, lipoproteins, and inflammatory debris smooth 5. Plaques slowly enlarge, the orifice of the artery is Plaques decreased and perfusion is diminished decreased 6. Can lead to hypertension, cardiac (CAD) and renal Can disease, peripheral arterial disease, stroke and myocardial infarction infarction Pathogenesis of Atherosclerosis* Atherosclerosis* It is characterized by localized fibrous thickenings of the It arterial wall associated with lipid-infiltrated plaques that may eventually calcify. may Old plaques are prone to ulceration and rupture, triggering Old the formation of thrombi that obstruct flow. Leads to vascular insufficiency in the limbs, abnormalities of the renal circulation, and dilations (aneurysms). of Leads to common severe and life-threatening diseases of Leads the heart and brain because of formation of intravascular clots at the site of the plaques. Possibility---high concentrations of cholesterol in the serum in the form of low-density lipoproteins are transported into muscle tissues of an artery where they cause irritation. muscle This process causes structural alterations leading to the This formation of plaque. formation Progression of Atherosclerosis Atherosclerosis Cholesterol/Plaque Cholesterol/Plaque Atherosclerosis Atherosclerosis Clinical Manifestations Clini...
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This document was uploaded on 03/25/2014.

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