Unformatted text preview: n the breast feeding infant.
• Drugs that are lipid soluble readily enter
breast milk. 14 Drug Therapy During Breast-Feeding
How to decrease risk to infant:
5. Minimize use of drugs
Take drugs immediately after breast-feeding.
Avoid drugs that have a long half-life & SR/ER formulations.
Choose drugs that tend to be excluded from milk and are least
likely to affect the infant.
Avoid drugs known to be hazardous (Category ?) 15 Critical Thinking Question
Explain why gestational weeks 3
through 8 are considered critical
when drug administration is
considered during pregnancy.
- Weeks 3-8 is major organ
development of the fetus 16 Critical Thinking Question
A patient at 34 weeks of gestation develops a lifethreatening gram-positive infection that is responsive to
carbenicillin. What interests of the mother and fetus are
most important here? Is this drug likely to cause
significant harm to either party? May treatment
reasonably be postponed?
Baby is in the 3 trimester so you can still deliver the baby.
You want to save both lives. You will give the mother
antibiotics, which wont hurt the mother or the baby.
Treatment may not be postponed. You will give the lowest
therapeutic dosage 17 Drug Therapy in
Pediatric Patients 18 Pediatric Patients
1. All patients under the age of 16 years
2. Respond differently to drugs than the rest of the population
• More sensitive to drugs than other patients are
Show greater individual variation
Sensitivity due mainly to organ system immaturity
Increased risk for adverse drug reaction
Drug therapy is individualized 19 Pediatric Patients Ongoing growth and development
Different age groups – different challenges
Two-thirds of drugs used in pediatrics have never been tested
in Unethical to test in peds
Unethical Two laws—both promote drug research in children
• Best Pharmaceuticals for Children Act – 2002
• Pediatric Research Equity Act of 2003 20 Pediatric...
View Full Document
- Spring '14
- Pharmacology, Teratogens