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Unformatted text preview: Receptor Agonists
•Adverse effects • Chest symptoms – Transient “heavy arms” or “chest pressure” experienced
by 50% of users • Coronary vasospasm – Rare angina secondary to vasospasm • Teratogenesis
– Vertigo, malaise, fatigue, tingling sensations
Very bad taste when taken in intranasal form
Don’t need to know
Don’t Serotonin1B/1D Receptor Agonists
Other serotonin1B/1D receptor agonists
(Relpax) Migraine Headache III
• Beta blockers- “olol”
– Preferred drugs for migraine prevention
Slow heart rate and blood pressure
Opposite of triptans
Opposite • Tricyclic antidepressants
• Antiepileptic drugs – Divalproex (Depakote ER)
– Topiramate (Topamax) • Estrogens and Triptans(for menstrual
migraine) frovatriptan or eletriptan
migraine) Migraine Headache III
• Other drugs for prophylaxis – Calcium channel blockers (verapamil)
– Candesartan, an angiotensin II receptor blocker
– Supplements: herbal
• Riboflavin or B2
Butterbur Cluster Headaches
Cluster • Characteristics
– Occur in a series or “cluster” of attacks
– Each attack lasts 15 minutes to 2 hours
– Severe, throbbing, unilateral pain near the eye
– Vasodilation occurs resulting in release of serotoin and
– Lacrimation, conjunctival redness, nasal congestion,
rhinorrhea, ptosis, miosis on the same side of the
– 1-2 attacks every day for 2-3 months
– An attack-free interval of months to years separates
– Primary therapy directed at prophylaxis Treatment of Cluster Headaches
•Oxygen Tension Headache
• Most common type of headache.
• Associated with pericranial muscle spasm which
causes decreased blood flow and muscle ischemia.
Serotonin levels may be decreased.
• Episodic nonpulsating mild to moderate headache
with or without neck muscle pain and tenderness.
• Usually bilateral and not associated with nausea or
photophobia. Pain is dull and persistent with
varying intensity. Occur frequently.
• May be associated with psychosocial stressors.
• Treatment---nonopioid analgesics and patient
teaching on how to manage stress.
teaching Critical Thinking Question
Tom complains of having migraine headaches
two to three times per month, and tells you
that the pain incapacitates him for hours
(severe). He wants to try sumatriptan
(Imitrix) because his friend has found it
helpful. How should Tom be assessed
before this medication is prescribed? If he
does receive a prescription for this
medication, what teaching needs wil...
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This document was uploaded on 03/25/2014.
- Spring '14