Anti-inflamm Antiallergic Immunologic Drugs- pharm

Cancer prevention prevention of alzheimers disease

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Unformatted text preview: t Used to treat inflammatory disorders Used (rheumatoid arthritis, osteoarthritis, bursitis) bursitis) – Alleviate mild to moderate pain – Suppress fever – Relieve dysmenorrhea Suppress inflammation but have risk of Suppress serious harm serious Aspirin Aspirin Nonselective inhibitor of cyclooxygenase Therapeutic uses – Analgesic, antipyretic, anti-inflammatory – Suppression of platelet aggregation Protects in thrombotic disorders – Dysmenorrhea – ? Cancer prevention – ? Prevention of Alzheimer’s disease Aspirin Aspirin Adverse effects – Gastrointestinal effects – Bleeding – Renal impairment – Salicylism – too high (tinnitus, sweating, Salicylism headache, dizziness) headache, – Reye’’s syndrome (away from children with s influenza or chickenpox) influenza – Pregnancy Anemia, postpartum hemorrhage Anemia, Aspirin Aspirin Drug interactions – Anticoagulants: warfarin and heparin – Glucocorticoids (suppress immune system) – Alcohol – Ibuprofen Acute poisonings Nonaspirin First-Generation NSAIDs Nonaspirin Aspirin-like drug with fewer GI, renal, and hemorrhagic Aspirin-like effects than aspirin effects 20+ nonaspirin NSAIDs available (all similar, but for 20+ unknown reasons, patients tend to do better on one drug or another or Inhibit COX-1 and COX-2 – inhibition is reversible (unlike Inhibit with aspirin) with Principal indications – rheumatoid arthritis and Principal osteoarthritis osteoarthritis Do not protect against MI a...
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This document was uploaded on 03/25/2014.

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