Anti-inflamm Antiallergic Immunologic Drugs- pharm

Thrombocytopenia mutagenic and teratogenic neoplasms

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Unformatted text preview: ine (Imuran) Azathioprine – Suppresses cell-mediated and humoral Suppresses immune responses immune Therapeutic uses – Treatment with transplants – Autoimmune disorders Adverse effects – Neutropenia – Thrombocytopenia – Mutagenic and teratogenic – Neoplasms Other Cytotoxic Drugs Other Cyclophosphamide (Cytoxan, Neosar) – Anticancer drug Methotrexate (Rheumatrex, Trexall) – Anticancer agent – Autoimmune disorders – Suppression of B and T lymphocytes Mycophenolate mofetil (CellCept, Myfortic) – Approved for prophylaxis of organ rejection – Acts on B and T lymphocytes to inhibit inosine Acts monophosphate dehydrogenase monophosphate – Selective inhibition of B and T lymphocyte Selective proliferation proliferation Antibodies Antibodies Muromonab-CD3 (Orthoclone OKT3) – Monoclonal antibody Actions and uses – Blocks all T-cell function – Prevents acute rejection of transplants – Depletes T cells prior to bone marrow transplant Adverse effects – Fever – Chills – Dyspnea – Chest pain – Nausea and vomiting Nursing Implications for immunosuppressants* immunosuppressants* Monitor vital signs – Specifically temperature (it will go up) – Then BP and HR (BP drops when ill, so heart wants Then to speed up) to Assess for signs of edema – Puffy in the lower extremities Puffy Monitor CBC – Specifically neutrophils (WBC) Administer a non-opioid analgesic for minor symptoms –...
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