Anti-inflamm Antiallergic Immunologic Drugs- pharm

Hyperplasia anaphylaxis with iv administration

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Unformatted text preview: s Adverse effects – – – – – – – – – Nephrotoxicity is the major concern Neurotoxicity GI effects Hypertension Hyperkalemia Hyperglycemia Hirsutism Gum hyperplasia Anaphylaxis with IV administration Sirolimus (Rapamune) Sirolimus Actions and therapeutic use – Only for prevention of renal transplant rejection – Use in conjunction with cyclosporine and Use glucocorticoids glucocorticoids Adverse effects – Increased risk of infection – Raises levels of cholesterol and triglycerides – Risk of renal injury – Severe complications in the liver and lung – Rash, acne, anemia, thrombocytopenia, joint Rash, pain, diarrhea, hypokalemia pain, Glucocorticoids Glucocorticoids Used to widely suppress immune Used response response – Suppression of allograft rejection, treatment of Suppression asthma, rheumatoid arthritis, SLE, and multiple sclerosis multiple Large doses used to prevent rejection – Increased risk for infection, thinning of skin, Increased bone dissolution with fractures, impaired growth in children, and suppression of hypothalamic-pituitary-adrenal axis hypothalamic-pituitary-adrenal Cytotoxic Drugs Cytotoxic Suppress immune response by killing B Suppress and T lymphocytes undergoing proliferation proliferation Nonspecific – toxic to all proliferating cells Adverse effects Bone marrow suppression – Neutropenia – Thrombocytopenia Thrombocytopenia GI disturbances Reduced fertility Alopecia Cytotoxic Drugs Cytotoxic Azathiopr...
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This document was uploaded on 03/25/2014.

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