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Anti-inflamm Antiallergic Immunologic Drugs- pharm

Parietal cells to promote act acid release acid

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Unformatted text preview: can cause hypotension Increased capillary permeability – Edema Bronchoconstriction – Not the cause of asthma attack CNS effects – Role in cognition, memory, and Role sleep/waking cycles sleep/waking Other – Itching, pain, secretion of mucus H2 Receptors Secretion of gastric acid Act directly on parietal cells to promote Act acid release acid Dominant role in acid release Histamine Antagonists/Antihistamines Histamine Act primarily on H1 and H2 receptors Used primarily for two pathologic states 1. Allergic disorders 2. Peptic ulcer disease Mild Allergic Responses Mild Caused largely by histamine acting at H1 receptors (in the skin and lungs) receptors Rhinitis, itching, localized edema Hay fever, mild transfusion reactions, Hay acute urticaria (hives) acute Usually responsive to antihistamine Usually therapy therapy Severe Allergic Responses Severe Anaphylaxis – Anaphylactic shock Bronchoconstriction, hypotension, edema of the Bronchoconstriction, glottis glottis Histamine plays a...
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