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Anti-inflamm Antiallergic Immunologic Drugs- pharm

Stroke 2005 two coxibs withdrawn from use 2005

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Unformatted text preview: nd stroke- don’t thin blood thin First-Generation NSAIDs First-Generation Ibuprofen (Advil, Motrin) Fenoprofen (Naflon) Flurbiprofen (Ansaid) Naproxen (Aleve) Naproxen plus lansoprazole (Prevacid NapraPAC) Oxaprozin (Daytril) Second-Generation NSAIDs Second-Generation Just as effective as traditional NSAIDs at Just suppressing inflammation and pain suppressing Somewhat lower risk for GI side effects Can impair renal function and cause Can hypertension and edema hypertension Increase the risk for MI and stroke – 2005, two coxibs withdrawn from use: 2005, rofecoxib (Vioxx) and valdecoxib (Bextra) – Use of celecoxib (Celebrex) has sharply Use declined declined Celecoxib (Celebrex) Celecoxib Second-generation COX-2 inhibitor—fewer Second-generation adverse effects than first-generation drugs adverse Because of cardiovascular risks, last-choice Because drug for long-term management of pain drug Uses Uses – Osteoarthritis – Rheumatoid arthritis – Acute pain – Dysmenorrhea – Familial adenomatous polyposis Celecoxib (Celebrex) Celecoxib Adverse effects – Dyspepsia – Abdominal pain – Renal toxicity – Cardiovascular impact (stroke, MI, and other Cardiovascular serious events) serious Celecoxib (Celebrex) Celecoxib Drug interactions – Warfarin – May decrease diuretic effect of furosemide – May decrease antihypertensive effect of ACE May inhibitors inhibitors – May increase levels of lithium Acetaminophen (Tylenol) Acetaminophen Ther...
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