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Receptor modulators serms modulators raloxifene evista

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Unformatted text preview: ism Selective Estrogen Receptor Modulators (SERMs) Modulators Raloxifene (Evista) – Does not activate estrogen/decreased risk of Does uterine cancer (why different from tamoxifen) uterine – Protects against breast cancer, osteoporosis – Promotes thromboembolism – Induces hot flashes Progestins Progestins Compounds that act like progesterone Principal endogenous progestational Principal hormone—prepares uterus for implantation hormone— Produced by ovaries and placenta Adverse effects – Teratogenic effects---1st trimester – Gynecologic effects – Breast cancer---increased risk – Depression – Breast tenderness Progestins Progestins Therapeutic uses – Postmenopausal hormone therapy – Dysfunctional uterine bleeding – Amenorrhea – Prematurity prevention – Endometrial carcinoma and hyperplasia Menopausal Hormone Therapy Benefits-HRT Therapy Relief of vasomotor symptoms Management of urogenital atrophy Prevention of osteoporosis and related fractures Prevention of colorectal cancer Positive effect on wound healing Glycemic control Manage symptoms caused by the loss of Manage estrogen in menopause/Hot flashes, sleep disturbances, urogenital atrophy, bone loss, altered lipid metabolism altered Use of HRT has declined sharply Menopausal Hormone Therapy Risks Therapy Cardiovascular events: myocardial Cardiovascular infarction, stroke, pulmonary embolism, and deep venous thrombosis and Endometrial cancer Breast cancer Ovarian cancer CVA Gallbladder disease Approved HRT Uses Approved 1. Treatment of moderate to severe Treatment vasomotor symptoms associated with menopause. menopause. 2. Treatment of moderate to severe Treatment symptoms of vaginal atrophy associated with menopause. with 3. Prevention of postmenopausal Prevention osteoporosis. osteoporosis. Premenstrual Syndrome Generally develop during the luteal phase of the menstrual Generally cycle---neuroendocrine orgin. cycle---neuroendocrine Psychological symptoms---irritability, depression, m...
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