Unformatted text preview: ism Selective Estrogen Receptor
Modulators (SERMs)
Modulators
Raloxifene (Evista) – Does not activate estrogen/decreased risk of
Does
uterine cancer (why different from tamoxifen)
uterine
– Protects against breast cancer, osteoporosis
– Promotes thromboembolism
– Induces hot flashes Progestins
Progestins
Compounds that act like progesterone
Principal endogenous progestational
Principal
hormone—prepares uterus for implantation
hormone—
Produced by ovaries and placenta
Adverse effects
– Teratogenic effects---1st trimester
– Gynecologic effects
– Breast cancer---increased risk
– Depression
– Breast tenderness Progestins
Progestins
Therapeutic uses – Postmenopausal hormone therapy
– Dysfunctional uterine bleeding
– Amenorrhea
– Prematurity prevention
– Endometrial carcinoma and hyperplasia Menopausal Hormone
Therapy Benefits-HRT
Therapy
Relief of vasomotor symptoms
Management of urogenital atrophy
Prevention of osteoporosis and related fractures
Prevention of colorectal cancer
Positive effect on wound healing
Glycemic control
Manage symptoms caused by the loss of
Manage
estrogen in menopause/Hot flashes, sleep
disturbances, urogenital atrophy, bone loss,
altered lipid metabolism
altered
Use of HRT has declined sharply Menopausal Hormone
Therapy Risks
Therapy
Cardiovascular events: myocardial
Cardiovascular
infarction, stroke, pulmonary embolism,
and deep venous thrombosis
and
Endometrial cancer
Breast cancer
Ovarian cancer
CVA
Gallbladder disease Approved HRT Uses
Approved
1. Treatment of moderate to severe
Treatment vasomotor symptoms associated with
menopause.
menopause.
2. Treatment of moderate to severe
Treatment
symptoms of vaginal atrophy associated
with menopause.
with
3. Prevention of postmenopausal
Prevention
osteoporosis.
osteoporosis. Premenstrual Syndrome
Generally develop during the luteal phase of the menstrual
Generally
cycle---neuroendocrine orgin.
cycle---neuroendocrine
Psychological symptoms---irritability, depression, m...
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Full Document
- Spring '14
- Pharmacology, Prostate cancer, estrogen, Infertility, Combined oral contraceptive pill
-
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