And responsible for the following stimulation of

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Unformatted text preview: estes, ovaries, and adrenal cortex Include testosterone and other related hormones. Male sex hormones necessary for normal development Male and maintenance of male sex characteristics. and Responsible for the following: Stimulation of spermatogenesis Development of secondary sex characteristics Sexual maturity at puberty Primary clinical application is management of androgen Primary deficiency in males (male hypogonadism). deficiency Principal adverse effects are virilization and Principal hepatotoxicity. hepatotoxicity. Testosterone is the principal endogenous androgen Testosterone Testosterone Prototype of androgen hormones Effects on sex characteristics in females Anabolic effects – Skeletal muscle Erythropoietic effects – Synthesis of erythropoietin – Men have greater hematocrit than women Clinical Pharmacology of the Androgens Androgens Therapeutic uses – Male hypogonadism---primary use Replacement therapy – Delayed puberty – Breast cancer---advanced – Wasting in patients with AIDS---increase muscle Wasting mass mass – Anemias Clinical Pharmacology of the Androgens Androgens Adverse effects – Virilization- inability to produce the sperm with Virilizationsomething in it something – Premature epiphyseal closure: stunt the Premature growth – Hepatotoxicity – Effects on cholesterol levels – Use in pregnancy – Prostate cancer – Edema – Gynecomastia- growing female breasts Gynecomastia– Abuse potential (athletic performance) Anabolic Steroids Anabolic Testosterone-like compounds with Testosterone-like hormonal activity. hormonal Taken by athletes to build muscle mass Taken and strength. and Taken in large doses may produce side Taken effects that last for months. effects Most androgens are classified as Most Schedule III drugs because of their abuse potential. potential. Androgen (Anabolic Steroid) Abuse by Athletes Abuse Many athletes use to enhance athletic Many performance performance Significant risks – Hypertension, suppression of release of LH Hypertension, and FSH, testicular shrinkage, sterility, testicular sterility, gynecomastia, acne, reduction of HDL and increase of LDL increase – Hepatotoxicity Hepatotoxicity – Psychological effect...
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