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Unformatted text preview: estes, ovaries, and adrenal cortex Include testosterone and other related hormones. Male sex hormones necessary for normal development
Male and maintenance of male sex characteristics.
and Responsible for the following: Stimulation of spermatogenesis
Development of secondary sex characteristics
Sexual maturity at puberty Primary clinical application is management of androgen
Primary deficiency in males (male hypogonadism).
deficiency Principal adverse effects are virilization and
hepatotoxicity. Testosterone is the principal endogenous androgen Testosterone
Prototype of androgen hormones
Effects on sex characteristics in females
– Skeletal muscle
– Synthesis of erythropoietin
– Men have greater hematocrit than women Clinical Pharmacology of the
– Male hypogonadism---primary use
Replacement therapy – Delayed puberty
– Breast cancer---advanced
– Wasting in patients with AIDS---increase muscle
– Anemias Clinical Pharmacology of the
– Virilization- inability to produce the sperm with
Virilizationsomething in it
– Premature epiphyseal closure: stunt the
– Effects on cholesterol levels
– Use in pregnancy
– Prostate cancer
– Gynecomastia- growing female breasts
Gynecomastia– Abuse potential (athletic performance) Anabolic Steroids
Testosterone-like compounds with
Testosterone-like hormonal activity.
Taken by athletes to build muscle mass
Taken in large doses may produce side
effects that last for months.
Most androgens are classified as
Schedule III drugs because of their abuse
potential. Androgen (Anabolic Steroid)
Abuse by Athletes
Many athletes use to enhance athletic
Significant risks – Hypertension, suppression of release of LH
and FSH, testicular shrinkage, sterility,
gynecomastia, acne, reduction of HDL and
increase of LDL
– Psychological effect...
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- Spring '14