Etiologies decreased libidoreduced sex drive

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Unformatted text preview: s---could intensify Psychological aggression aggression Drugs for Erectile Dysfunction and Benign Prostatic Hyperplasia Hyperplasia Types of Sexual Dysfunction Types May have both medical and psychological May etiologies. etiologies. Decreased libido/reduced sex drive Difficulty in arousal Erectile dysfunction (impotence) in men Reduced vaginal lubrication in women Inability to have an orgasm Pain with sexual stimulation Infertility Erectile Dysfunction Erectile ED – also known as impotence ED – A persistent inability to achieve or sustain an persistent erection suitable for satisfactory sexual performance performance Affects up to 30 million men Affects ED commonly associated with chronic ED illnesses (diabetes, hypertension, vasodilators) vasodilators) Risk for ED increases with advancing age Treatment for ED Treatment Drugs – Oral agents – PDE5 inhibitors Sildenafil ((), vardenafil Sildenafil (), and tadalafil () (), – Nonoral agents Papaverine plus phentolamine, and Papaverine alprostadil alprostadil Sildenafil () Sildenafil Phosphodiesterase type 5 (PDE5) inhibitor I Generally well tolerated – Can be dangerous if used concurrently with certain Can vasodilators (alpha-adrenergic blockers and nitrates) vasodilators Only enhances normal erectile response in the Only presence of stimuli presence – No significant impact on men who do not have ED – Not approved for women Sildenafil () Sildenafil Adverse effects – Hypotension- its similar to a vasodilator Hypotension– Priapism- painfully long erection (give an Priapismalpha blocker for this) alpha – Headache, dyspepsia, flushing, nasal Headache, congestion, diarrhea, rash, dizziness, mild transient visual disturbances, intensification of obstructive sleep apnea obstructive – Rare side effects Nonarteritic ischemic optic neuropathy Sudden hearing loss Sildenafil () Sildenafil Absorption slowed by high-fat meals Drug interactions – Nitrates Could cause life-threatening hypotension 24 hours in between these meds for safety – Alpha blockers Can cause symptomatic postural hypotension – Inhibitors of cytochrome P450 (CYP3A4) Inhibitors Can suppress metabolism of sildenafil Sildenafil () Sildenafil Drug should be used with caution by men Drug with the following conditions: with – MI, stroke, and life-threatening dysrhythmia MI, within the last 6 months- they’d be on an aspirin and beta blocker – Resting hypotension (BP below 90/...
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