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Factors disorders male pituitary disorders chronic

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Unformatted text preview: se defects, damaged fallopian tubes, endometriosis, uterine leiomyomas, adhesions, cervical factors. factors. Disorders--male---pituitary disorders, chronic disease, ---pituitary testicular disorders, varicocele, drugs, infection, congenital problems. Drugs Used for Infertility Drugs Drugs given to promote oocyte maturation Drugs and ovulation. and Ovulation stimulants used to treat infertility Ovulation in women. in Causes of Female Infertility Causes Anovulation and failure of follicular Anovulation maturation maturation Unfavorable cervical mucus Hyperprolactinemia Endometriosis Polycystic ovary syndrome (POS) Drugs Used to Treat Female Infertility Infertility Drugs for controlled ovarian stimulation – Facilitation of follicular maturation and Facilitation ovulation ovulation – Fertilization can be natural or assisted Fertilization reproduction reproduction – Mechanisms of action Promote follicular maturation Stimulate ovulation Prevent premature stimulation of ovulation by Prevent endogenous hormones endogenous Drugs Used to Treat Female Infertility Infertility Clomiphene (Clomid, Milophene, Serophene) – Used to promote follicular maturation and ovulation--causing increase release of LH & FSH – Used for difficulty getting pregnant – Blocks receptors for estrogen – Adverse effects Hot flashes Gastrointestinal: nausea, bloating Abdominal discomfort Breast engorgement Visual disturbances: blurred vision Multiple births DOC for female infertility Drugs Used to Treat Female Infertility Infertility Menotropins (Pergonal, Repronex, Menopur) – Mixture of LH and FSH – Used in conjunction with hCG to promote follicular Used maturation and ovulation in anovulatory patients maturation – Adverse effects Ovarian hyperstimulation syndrome---sudden -sudden enlargement of the ovaries*** enlargement Multiple births Drugs Used to Treat Female Infertility Infertility Human Chorionic Gonadotropin (hCG) – Given to stimulate ovulation – A hormone produced by the placenta – Therapeutic use Promotes follicular maturation and ovulation – Adverse effects Ovarian hyperstimulation syndrome Edema Injection site pain Central nervous system disturbances – Headache, irritability, restlessness, fatigue Drugs for Endometriosis Drugs Leuprolide (Lupron Depot, Eligard) IM injection Leuprolide – – – – Reduce symptoms but does not increase infertility Synthetic analog of GnRH Suppresses ovarian...
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