The nitrate family nitrate vardenafil levitra

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Unformatted text preview: 50 mm Hg) – Resting hypertension (BP above 170/110 mm Resting Hg) Hg) – Heart failure- they would be on digoxin Heart – Unstable angina- nitrates Unstable – Sildenafil should not be used at all by men Sildenafil taking nitroglycerin or any other drug in the nitrate family** nitrate Vardenafil () Vardenafil PDE5 inhibitor II Relaxes arterial and trabecular smooth Relaxes muscle in the penis muscle – Adverse effects Headache and flushing Rhinitis and dyspepsia Can prolong QT interval Can lower blood pressure Can also be associated with sudden hearing loss Can and vision loss from nonarteritic ischemic optic neuropathy (NAION) neuropathy Vardenafil () Vardenafil Drug interactions – Nitrates Could cause life-threatening hypotension 24 hours in between these meds for safety – Alpha blockers Can cause symptomatic postural hypotension – Inhibitors of cytochrome P450 (CYP3A4) Inhibitors Can suppress metabolism of vardenafil Tadalafil () Tadalafil PDE5 inhibitor II – Relaxes the penile and arterial and trabecular Relaxes smooth muscle smooth – Effects last up to 36 hours (longest of the Effects three PDE5 inhibitors) three – Also now approved for daily dosing if activity Also anticipated twice weekly anticipated Tadalafil () Tadalafil Adverse effects – Headache, dyspepsia, back pain, myalgia, Headache, limb pain, flushing, nasal congestion limb – Can also be associated with sudden hearing Can loss and vision loss loss Drug interactions – Nitrates – Alpha blockers Other Drugs for ED Treatment Other Papaverine (smooth muscle relaxant) plus phentolamine (alpha-adrenergic blocking agent) blocking – Increased arterial flow and decreased venous Increased outflow in the penis outflow – Used to counteract impotence – Administration Injected directly into the corpus cavernosum – Adverse effects Priapism Painless fibrotic nodules in the corpus cavernosum Orthostatic hypotension with dizziness Other Drugs for ED Treatment Other Alprostadil (prostaglandin E1) – Administration Injected directly into the corpus cavernosum Increased arterial flow and decreased venous Increased outflow in the penis outflow Should not be used more than 3 x/week or 1 x/24 Should hours hours – Adverse effects Burning sensations, prolonged erection, priapism, Burning and penile fibrosis and – Transurethral—alprostadil pellets (Muse) Do not use more than 2 x/24 hours No priapism or penile fibrosis Drugs That Can Adversely...
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This document was uploaded on 03/25/2014.

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