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24 fig 13 7 p 291 bio 1140 unit 2 2 transcription

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Unformatted text preview: 91 BIO 1140 Unit 2-2: Transcription Alternative mRNA Splicing α-tropomyosin in smooth and striated muscle 25 Fig. 13-9, p. 293 BIO 1140 Unit 2-2: Transcription Pre-mRNA Processing 4. mRNA Capping: A cap attached to the 5´ end of the mRNA results in more efficient translation. (don’t memorize the structure, just call it a 7MeG cap). 5. Polyadenylation: 3’ to the signal AAUAAA, polyA polymerase adds ~50-250 adenine nucleotides to form the “Poly(A) tail” Proteins bind to the “tail” and protect mRNA from RNA-digesting enzymes 6. Nucleoside modification (Unit 1, Supplemental Info) 26 BIO 1140 Unit 2-2: Transcription Pre-mRNA Processing 7. RNA Editing: Specific bases in the RNA are changed. Some examples are a C in the RNA becomes a uracil (U) (cytidine deaminase) this can change a codon if in the open reading frame (ORF) an A in the RNA becomes an inosine (I): (adenosine deaminase) the ribosome translates I as a G thus changing a codon in the ORF. These changes can lead to changes in the protein and its function, or splicing or may have no function at all! 27 BIO 1140 Un...
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